| Journal Article |
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| Article Title | Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry | | Author | Dilani D. De Silva, Sylvie Rapior, Enge Sudarman, Marc Stadler, Xu Jianchu, S. Aisyah Alias and Kevin D. Hyde | | Year | 2013 | | Journal Title | Fungal Diversity | | Institution | Mushroom Research Foundation | | Volume | 62 | | Pages | 1–40 | | Call Number | JA0556-14 | | Keywords | Medicinalmushrooms, Anti-oxidant, Anti-tumor, Anti-HIV, Anti-microbial, Anti-viral, Hypocholesterolemic, Anti-diabetic, Anti-Alzheimer, Anti-malarial, Food supplements |
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| Abstract: |
| Exploration of natural sources for novel bioactive
compounds has been an emerging field of medicine over the
past decades, providing drugs or lead compounds of considerable
therapeutic potential. This research has provided exciting
evidence on the isolation of microbe-derived metabolites
having prospective biological activities. Mushrooms have
been valued as traditional sources of natural bioactive
compounds for many centuries and have been targeted as
promising therapeutic agents. Many novel biologically active
compounds have been reported as a result of research on
medicinal mushrooms. In this review, we compile the information
on bioactive structure-elucidated metabolites from
macrofungi discovered over the last decade and highlight their
unique chemical diversity and potential benefits to novel drug
discovery. The main emphasis is on their anti-Alzheimer, antidiabetic,
anti-malarial, anti-microbial, anti-oxidant, antitumor,
anti-viral and hypocholesterolemic activities which
are important medicinal targets in terms of drug discovery
today. Moreover, the reader’s attention is brought to focus on
mushroom products and food supplements available in the
market with claimed biological activities and potential human
health benefits. |
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